When someone finds a trial they are interested in they will typically complete an online pre-screening questionnaire to determine if the trial is a good fit. If so, they will be referred to a local research site, or a physician office conducting the trial, for further screening.

If a patient would like to move forward with a more in-depth screening, they first need to review the informed consent form (ICF). This form will include information on:

• The frequency of visits to the trial site.
• What will be required at the visits, such as physical exams, questionnaires, or other procedures.
• Possible benefits and risks of trial participation.

It is important that patients ask their researcher, doctor, and research staff any questions about participation they may have. If a patient reviews the information and would like to move forward, they must sign an informed consent form. By signing this form, the patient is acknowledging that they understand the clinical trial process and their rights and responsibilities, including the ability to leave the study at any time.

During participant screening, researchers may check medical history and conduct a physical exam to make sure all requirements for joining the trial are met. The screening process will differ for each study based on the eligibility criteria that determine who can participate.

Researchers will walk the participant through next steps, which may include recieving an investigational drug. Participants will also receive guidance on what to do while at home and information about the timing of their next appointment.

During the clinical trial, the participant may have routine visits to the research team where various exams, questionnaires, and/or additional procedures may be conducted. A participant’s overall health and safety will be continually monitored during the entire length of the study.

Once participation has ended, research staff will discuss the next steps with the participant. This could include meeting with a regular healthcare provider to determine further care options.